Browsing by Author "Khan, Waqas"

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    • Generation of the short TRIM32 isoform is regulated by Lys 247 acetylation and a PEST sequence 

      Garcia-Garcia, Juncal; Overå, Katrine Stange; Khan, Waqas; Sjøttem, Eva (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-17)
      TRIM32 is an E3 ligase implicated in diverse biological pathways and pathologies such as muscular dystrophy and cancer. TRIM32 are expressed both as full-length proteins, and as a truncated protein. The mechanisms for regulating these isoforms are poorly understood. Here we identify a PEST sequence in TRIM32 located in the unstructured region between the RING-BBox-CoiledCoil domains and the NHL ...

    • A study of TRIM32 self-ubiquitination 

      Khan, Waqas (Master thesis; Mastergradsoppgave, 2020-05-15)
      TRIMs (tripartite motif proteins) constitute a family of ubiquitin E3 ligases that are involved in a variety of cellular processes including autophagy and carcinogenesis. TRIM32 contains an N-terminal RING finger domain, B-box region, a coiled-coil domain and six NHL repeats in the C-terminal region, which are involved in protein dimerization and substrate recognitions. Various mutations in the NHL ...